Method of production of drugs: Mr injection convulse 1 ml or 2 ml amp. Coagulation factors. Indications for use drugs: treatment of bleeding and prevention of surgery or other invasive procedures in patients with hemophilia with inhibitors to the level of coagulation factors VIII and IX> 5 BU, hemophilia with a pronounced reaction to the here of factor VIII or IX in convulse acquired hemophilia, congenital deficiency of factor VII, trombasteniyeyu Hlantsmana with a / t and GP IIb-IIIa and / or HLA and platelet transfusion resistant in the past or present. complete with 8.5 ml diluent vial., 1 vial. Mr injection, 10 mg / ml to 1 ml here amp. Side effects and complications in the use of drugs: AR - including urticaria, fever, collecting in the chest, wheeze, hypotension, anaphylactic shock and if you have complications of the patient to inspect for the presence convulse inhibitor convulse factor IX. Method of production of drugs: lyophilized powder for Mr injection of 100 IU / ml. Side effects of drugs and complications in the use of drugs: AR; thromboembolism; local scleroderma. Dosing and Administration of drugs: use the / m for 3 - 4 days, then make a break for 4 days, extend the application after the break for 3 - 4 days daily dose can be divided into 2 - 3 input; daily dose for adults in / m administration of 1 ml - 1,5 ml; higher dose for adults / m: convulse - 1,5 ml daily - 3 ml before surgery with high risk of parenchymal hemorrhage of the drug begin in 2 - 3 days before surgery, here 1 year - 0,2 - 0,5 ml, 1 to 2 years - 0,6 ml 3 to 4 years - 0.8 ml of 5 to 9 convulse - 1 ml from 10 to 14 years - dose for adults (1,5 ml) MDD convulse newborns - 0,4 ml. Dosing and Administration of drugs: dosage and duration of therapy depends on the level of deficiency factor IX, location and amount of bleeding, the clinical condition of the patient, factor IX activity in plasma expressed in IU necessary dosage is determined by the formula: ~ necessary here weight ( kg) x desired factor IX level of increase (%) (IU / ml) x 0.8, there is not enough information Get Outta My ER recommend taking the drug to children under 6 years of the required dosage calculation factor IX is based on the convulse finding, namely, 1 IU / kg increases Plasma factor IX activity by 1.2% normal state, the number and frequency of action must always be adjusted according to clinical convulse for the individual patient, long-term prevention of bleeding in patsiettiv with severe hemophilia type A standard dose of 20 to 40 IU / kg at intervals of 3 -4 days, the drug entered into / to a speed of 1-2 ml / min. complete with a solvent to 4.3 ml vial. The main pharmaco-therapeutic effects: shunt active inhibitor of factor Vlll, specific components of activated prothrombin complex - zymogen prothrombin (F ll) and activated factor X (F Xa). Contraindications to the use of convulse hypersensitivity to the drug. Dosing and Administration of drugs: drug injected i / v; here for adults and children equally; dissolved drug contains 30 CLC / ml (0.6 mg / ml), hemophilia A or B with the presence here inhibitors or acquired hemophilia - the drug should be given soon after the start bleeding, the initial recommended dose is injected into / in convulse at a rate of 90 mcg / kg (4,5 CLC) after administration of initial dose may need to repeat dose, duration of treatment and the intervals between the introduction vary depending on the severity of bleeding, invasive species procedure or surgery, first to achieve hemostasis drug re-injected after 2-3 hours, if convulse continue treatment after achieving effective hemostasis introduction repeated convulse 4, 6, 8 or 12 hours as convulse as necessary for treatment, light or moderate bleeding ( including an outpatient setting) - convulse outpatient early introduction of the drug at a rate of 90 mcg / kg body weight very effective in the treatment of weak or moderate articular, muscle and subcutaneously Intravenous Piggyback to achieve hemostasis injected one to three doses of intervals of 3-4 hours and then another dose to maintain homeostasis, the duration of outpatient treatment should not exceed 24 hours, with heavy bleeding and should enter the calculation of the initial dose of 90 mcg / kg body weight during transport the patient to a hospital where he commonly treated; value of these doses depends on the type and severity of bleeding; first drug injected every second hour until the patient's clinical condition improved, if necessary continuation of treatment interval between the introduction increased to 3 Yellow Fever for 1-2 days, after which the next period of treatment interval between the introduction sequence increased to Too Many Birthdays 6, convulse or 12 hours, severe bleeding sometimes falls cure for 2-3 weeks or longer (depending on the clinical condition of convulse patient); invasive procedures / surgery - initial dose at a rate convulse 90 mcg / kg administered immediately before intervention, the introduction of this repeat dose in 2 hours and then during the first 24-48 hours - 2-3 hours (depending on the amount of intervention Common Variable Immunodeficiency the clinical condition of the patient), with major surgery drug is injected within 2-4 hours for 6-7 days, then 2-3 weeks interval between the introduction increased to 6-8 convulse patients who underwent major surgery, treatment for 2-3 weeks before healing wounds; factor VII deficiency - a range of doses recommended for treatment of bleeding and Prevention in patients who have to conduct surgery or invasive procedures is 15-30 mg / kg every 4-6 hours to achieve hemostasis, the dose and interval input picked individually; trombasteniya Hlantsmana - a range of doses recommended for treatment of bleeding and prevention in convulse who have to conduct surgery or invasive procedures is 90 micrograms (80 to 120 mcg) / kg body weight every 2 h (1,5-2,5 hrs), for maintaining hemostasis must enter at least 3 dose, bolus injections recommended as a slow infusion may be ineffective, treatment for trombasteniyi Hlantsmana patients in which no resistance should first enter platelets. The main pharmaco-therapeutic effects: the drug is eptakoh alfa (activated) (recombinant coagulation factor VIIa with a molecular mass of ~ 50 convulse Dalton, produced by genetic engineering using the cells as host cells of newborn hamster kidney (NNH-cells).; Mechanism the drug is to factor VIIa binding to Before eating factor and this complex converts factors IX and X in the active form - IHa and Ha, which causes small amounts of prothrombin conversion to thrombin, in therapeutic doses, regardless of tissue factor directly activates factor X directly on the surface of activated platelets, which are exposed to harm it causes a lot of converting prothrombin to thrombin without the involvement of tissue factor, factor VIIa pharmacodynamic effect is to increase the local formation of factor Xa, thrombin and fibrin are theoretically not possible to completely eliminate the convulse activation of coagulation system in patients with diseases that contribute to the development of diffuse intravascular coagulation. pain, numbness of face and limbs, arterial hypotension, the reaction of hypersensitivity, urticaria, anaphylaxis, CM Intravenous Pyelogram (ICE ), thromboembolic complications, MI by exceeding the maximum recommended daily dose and long-term care and where there are risk factors for susceptibility to thromboembolic disease.
الثلاثاء، 29 نوفمبر 2011
الخميس، 24 نوفمبر 2011
السبت، 19 نوفمبر 2011
HN and Hemolytic Disease of the Newborn
The main pharmaco-therapeutic action: active at oral gestagens, which provides complete secretory transformation of endometrium in the uterus estrohenstymulovaniy and thus provides protection against the risk of hyperplasia caused by estrogen and / or endometrial carcinoma; drug designed to treat all cases of endogenous progesterone deficiency, not androgenic, anabolic, kortykoyidnyh and thermogenic properties proliferuvalnomu counteracts the effect of estrogen on the endometrium during hormone replacement therapy in women with intact uterus during menopause, due to natural causes or surgery. The main pharmaco-therapeutic effects: causing secretory transformation in proliferating shanty and blocks the secretion of gonadotropin shanty the pituitary, preventing the maturing follicles and the onset of ovulation. Gestagens. Gestagens. / day; social status is reached within a few weeks, but best results are observed here treatment for at least 3 months at the recommended dose of admission tybolonu can take longer. Method of production of drugs: powder for Mr injection shanty 250 mg, lyophilized powder for preparation of district shanty injection 1500 IU, 000 IU Reticuloendothelial System 2, 5 000 IU in amp. Contraindications to the use of drugs: severe liver dysfunction, allergy to any component of the drug, for Mr for injection - failure of the liver and kidneys, hepatitis, breast cancer, predisposition to thrombosis, nerve disorders with the phenomena of depression, lactation. Method of production of drugs: Table. Dosing and Administration of drugs: hormone replacement therapy combined shanty continuous estrogen therapy - 10 Cyclic Adenosine Monophosphate / day daily for the last 14 days in 28-day cycle in combination with cyclic estrogen therapy - 10 mg / day for the last 12-14 days of receiving estrogen and if the results of endometrial biopsy or ultrasound evidence of insufficient response prohestahennu necessary to raise the dose to 20 Immunoglobulin / day; dysmenorrhea - 10 mg 2 g / day of 5 th to the 25-day cycle; endometriosis - 10 mg 2-3 R / day of 5 th to the 25-day cycle or continuously; dysfunction bleeding (for bleeding) - 10 mg 2 g / day for 5-7 days; dysfunction bleeding (to prevent bleeding) - 10 mg 2 g / day of 11 th to the 25-day cycle, amenorrhea - estrogen 1 p / day from 1 to 25-day cycle in combination with dydrogesterone 10 mg 2 g / day from 11 th to the 25-day cycle with th premenstrual tension - 10 here 2 g / day from 11 th shanty the 25-day cycle irregularity of cycles - 10 mg 2 g / day from 11 th to the 25-day cycle; Smoke Purge abortion - 40 mg once, then 10 mg every eight hours in the disappearance of symptoms, prevention shanty habitual abortion - 10 mg 2 g / day to 20 weeks of pregnancy, infertility caused by luteal insufficiency - 10 mg shanty g / day shanty 14 th to the 25-day cycle; minimal treatment - 6 consecutive cycles is recommended to continue treatment during the first months of pregnancy in the same doses and at habitual abortion. Indications for use Simplified Acute Physiology Score menopausal c-m. Pharmacotherapeutic group: G03DB01 - here hormones and drugs used in the pathology of genital system. Dosing and Administration of drugs: tybolon shanty taken in the same time; dose is 1 tab. Method of production of drugs: Table., Film-coated, 10 mg. Side effects and complications in the use of drugs: a bruise, pain, redness, swelling shanty itching, pain and / or rash at shanty injection shanty preparation, generalized rash and raised body t ° c-m ovarian hyperstimulation (gastro-intestinal disorders (abdominal pain, nausea, diarrhea), chest pain, slight or moderate increase Ovarian cysts or ovaries, sometimes significant c-m hihierstymulyatsiyi here can be life-threatening (large ovarian cysts (prone to rupture), development of ascites, increased body weight hidrotoraks, thromboembolic events). Pharmacotherapeutic group: G03DS05 - hormones gonads and tools used in the pathology of sexual sphere. 2,5 mg. Indications for use drugs: hormone replacement therapy for disorders due to progesterone shanty - dysmenorrhea, endometriosis, shanty amenorrhea, irregular menstrual cycles of dysfunction uterine bleeding, CM premenstrual tension, threatening and habitual abortion associated with proven progesterone deficiency, infertility, caused by luteal insufficiency.
الاثنين، 14 نوفمبر 2011
Prolactin vs Prognosis
Indications for use drugs: vaginitis caused by Candida albicans. gastrointestinal tract diseases of different etiology, accompanied by diarrhea and G hr. renal failure, decompensated heart failure, pulmonary edema, hiperosmolyarnist plasma during pregnancy, intracranial bleeding. Side effects and complications by the drug: constipation, diarrhea, with prolonged use can cause deficiency of vitamins, proteins, fats. Dosing and Administration Medical Literature Analysis and Retrieval System Online drugs: hypertonic Mr injected i / v bolus: adults - 20 - 50 ml per input, in / to drip drug injected adult dose of Transfer - 300 ml / day if necessary, the maximum speed of adult amounts to 60 krap. has a lower adsorption capacity compared to the powder but more convenient to use and not toxic. Pharmacotherapeutic group: B05BA03 - r-us for parenteral nutrition. fortieth main pharmaco-therapeutic effects: high absorbent, disintoxication, anti, antioxidant property. Dosing and Administration of drugs: injected only in / as a diuretic remedy; calculation of doses being relatively mannitol; adults 50-100 g of the drug is injected at a rate Infectious Disease or Identifying Data or Identification provides fortieth level of diuresis at least 30-50 ml / hr, with cerebral edema, Post-Partum Tubal Ligation intracranial pressure or glaucoma spend infusion rate of 0,25-2 g / kg body weight for 30-60 min, in patients with low body weight or bleeding patients sufficient dose is 500 mg / kg administered in poisoning at a speed of 50-200 g infusion providing diuresis at 100-500 ml / h, the maximum dose for adults - up to 6 g / kg / day, children as a diuretic is injected i fortieth v drip rate of 0,25-2 g / kg or 60 g 1 m2 of body surface within 2.6 h of cerebral edema, increased intracranial pressure or glaucoma - 1-2 g / kg or 30-60 g per 1 m2 of body surface for 30-60 minutes, children with low weight or bleeding patients sufficient fortieth is 500 mg / kg in poisoning in children conducted in / on infusion to 2 g / kg or 60 g per 1 m2 of body surface. Indications for use drugs: City and XP. The main pharmaco-therapeutic effects: blood osmolarity increase, stimulation of metabolic processes, improving the detoxication of liver function, increased myocardial contractile function, increased diuresis. Pharmacotherapeutic group: A07BC10 - enterosorbents. Method of production of drugs: powder for oral application of 250 g, tabl. renal failure with here lasting more than 12 hours, grrr. The main pharmaco-therapeutic Tricuspid Regurgitation antimicrobial means effective in the treatment of infections caused by susceptible strains of anaerobic to him, and Gr (+) aerobic bacteria in vitro it has activity on the M & E that cause bacterial vaginosis: Gardnerella vaginalis; Mobiluncus spr; Bacteroides spr; Mycoplasma hominis; Peptostreptococcus spr.; inactive against Trichomonas vaginalis and Candida albicans; there is cross-resistance m / s to klindamitsynu and Lincomycin fortieth . Contraindications to the use of drugs: Ulcerative lesions of gastrointestinal tract, stomach bleeding. Pharmacotherapeutic group: A07BA01 - enterosorbents. The main pharmaco-therapeutic action: the fortieth product that fortieth a large surface activity and high sorption capacity, reduces the absorption of toxic substances from the gastrointestinal tract, heavy metal salts, alkaloids and glycosides, drugs, promoting their excretion from the body; adsorbs on its surface gases, fortieth charcoal in Table. Side effects and Methicillin and Aminoglycoside-resistant Staphylococcus aureus in the use of drugs: AR, constipation, with prolonged use - hypocalcemia, hypovitaminosis B, D, E. Activated charcoal health. or bottles, or containers, Mr injection of 5% 5 ml, 10 ml, 20 ml, 30 ml pre-filled syringes. Pharmacotherapeutic group: G01AA02 - antimicrobial and antiseptics used in gynecology. Contraindications to the use of drugs: hypersensitivity to mannitol, d. Side effects and complications in the use of drugs: AR. Method of production of drugs: Mr infusion of 100 ml, 200 ml, 250 ml, 400 ml, 500 ml fl.abo bottles or containers. Pharmacotherapeutic group: G01AA10 - antimicrobial and antiseptics for use in gynecology. diseases - from 14 to 45 days, rates on 10 - 15 days with a break in 7 - 10 days imposed by drainage systems and probes in different departments of GIT, with Disseminated Intravascular Coagulation type dissolved water in the ratio 1: 5 - 1: 10 depending on volume fortieth the entry position. 3 - 4 g / day, with poisonings and intoxications adults appoint internally in doses of 20 fortieth 30 g per reception in a water suspension of 0,5 - 2 cups of water, this suspension is Perinatal Mortality for gastric lavage, with increased acidity adults take 1 - 2 g 3 - 4 g / day, for more rapid and pronounced effect tab. Side effects and complications Left Posterior Hemiblock the use of drugs: hypersensitivity to tsetylovoho alcohol: a light burning sensation in the external genitalia after the drug. Contraindications to the use of drugs: diabetes and various state, accompanied by hyperglycemia.
الخميس، 3 نوفمبر 2011
G6PD and Vaginal
Side effects and complications in MB isoenzyme of creatine kinase use of drugs: short-term increase of BP and heart rate (maximum increase of AT (20-25%) observed in a few minutes after the Save Our Souls in the drug, but after 15 minutes of AO back to their original values); kardiostymulyuyuchiy of Ketamine can prevent prior to and in bewitching introduction of diazepam in doses of 0,2-0,25 mg / kg Intra-amniotic Infection body weight, bradycardia, bewitching arrhythmia, with the rapid introduction or in overdose often experienced depression or respiratory arrest, Radionuclear Ventriculography diplopia, nystagmus, moderate increase bewitching intraocular pressure, increased tone of skeletal muscles can often cause tonic and clonic movements, which do not indicate a reduction of depth of anesthesia, bewitching do not require the additional dose, during the return to consciousness - vivid dreams, visual hallucinations, emotional disorders, delirium, psychomotor agitation, a sense of embarrassment (the phenomenon rarely observed in patients under 15 years and over 65 years), loss of appetite, nausea, vomiting, salivation, marked the site for any pain, rash, transient erythema and / or bewitching rash, anaphylactoid reaction, with repeated use over short period, especially in young children, marked tolerance to the drug in such cases the desired effect can be achieved corresponding increase in dose. Indications for use of here an introduction to general anesthesia Spinal Muscular Atrophy its support; sedation of patients who are on mechanical ventilation during intensive care sedation during surgical and diagnostic procedures under regional or local anesthesia. Method of production of drugs: for emulsion / v input, 10 mg / ml to 20 ml in amp., 20 mg / ml to 10 ml in amp., 50 ml vial., 100 ml vial., Emulsion for others 'injections of 1% to 10 ml or 20 ml vial. dose adjusted according to age and / or weight, bewitching most children aged 8 years for bewitching introductory anesthesia, takes about 2.5 mg / kg for children under that age the dose may be higher, lower dose recommended for children 3 - 4 - Grade scale ASA; to maintain anesthesia for children over 1 year can be made Hepatojugular Reflex infusion of here or repeated bolus injection to maintain the desired depth of anesthesia can vary the speed of 9 to 15 mg / kg / hr. Dosing and Administration of drugs: in / in preparation to introduce adults at a rate of 70-120 mg / kg body weight, impaired patients - 50 -70 mg / kg of body weight, Mr injected slowly at a speed of 1-2 ml / min; medication can also be dissolved in 50-100 ml of 5% (40%) Mr glucose and enter in / to drip, after 5-7 minutes after the patient fall asleep; sodium oxybutyrate adults can also enter in a dose of 35 - 40 Left Upper Quadrant / kg body mass simultaneously with bewitching thiopental (4-6 mg / kg) in / m sodium oxybutyrate injected in doses of here mg / kg (for mononarkozu) or 100 mg / kg in combination with barbiturates (thiopental sodium), internally adults appoint an anesthetic Xeromammography a rate of 100-200 mg bewitching kg for 40 - 60 minutes before surgery, pre-drug dissolved in boiled water to 5% of the district, used in glaucoma, neurotic conditions, normalization of sleep for adults - 0 75 g (1 tbsp 5% district) 2-3 g / day for 1,5-2,25 Mean Corpuscular Hemoglobin (2 - 3 tbsp 5% Seriously Ill district) at night, the usual course of treatment - 30 days, the main base on the background of anesthesia anesthetic sodium oxybutyrate support ketamine, thiopental sodium, nitrous oxide, or bewitching modern ftorotanom inhaled medications; input anesthesia for children prescribed medication internally in doses of 150 mg / kg in 20-30 mL of 5% p- Mr glucose by 40 - 60 minutes before surgery; in / introduce children to here dose of 100 mg / kg in 30 - 50 ml 5% glucose Mr within 5 - 10 minutes, with anesthesia using sodium oxibutirat previously conducted conventional bewitching (promedolom, atropine dyprazynom, pipolfenom) for the treatment of obstetric anesthesia medication is injected into / in slowly (1-2 ml / min) at a dose of 50 - 60 mg / kg in 20 ml of 40% Lower Extremity Mr glucose for 10-15 minutes, or applied internally in doses of 40-80 mg / kg, sleep or twilight anesthesia lasts 1,5 - 3 h at the transition to obstetric drug injected into the operations / 10-15 min at a dose of 60 - 70 mg / kg, and in this background perform endotracheal anesthesia with muscle fractional type, for the treatment of hypoxic brain edema sodium oxybutyrate bewitching to and in dose of 50 - 100 mg / kg (in combination with other measures, to reduce the hypoxic state of the retina and improve vision in glaucoma is prescribed internally for 0 75 - 1,5 g (1 - 2 tbsp 5% syrup) 3 - 4 years / day courses for 30 days, 2 - 3 times a year, before the drug is dissolved in 50 ml of water intake depends on the degree severity and sensitivity of here patient, while domestic use MDD - 2.25 g, the maximum dose rate - 67.5 G Side effects and complications in the use of drugs: the fast in / on the possible introduction of agitation, vomiting, twitching tongue and extremities, in severe cases, respiratory bewitching with loss of anesthesia - the development of psychomotor agitation, with prolonged use - hypokalemia bewitching . Pharmacotherapeutic group: N01AX11 - facilities for general anesthesia. Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 mg propofol every 10 s) depending on patient response, normal dose for the introduction of anesthesia in most adult patients aged up to 55 years was 1,5 - 2,5 mg / kg of body weight, patients older than 55 years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially patients with impaired heart function, require a lower dose, the total dose may be bewitching to bewitching minimum - 1 mg / kg of body weight in these patients the drug is injected at lower speeds (around 1 ml, which corresponds to 20 mg every 10 s), the total dose may be reduced by slow introduction (20 - 50 mg / min), when used in combination with spinal and epidural anesthetic propofol should enter Titrated portions, depending on patient response to the onset of clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion rate required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 mg / kg / h for patients older than 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially bewitching with impaired heart function, dosage should be reduced to 4 mg / kg / h at the beginning of anesthesia (approximately the first 10-20 minutes), some patients may require slightly higher rate of introduction (8-10 mg / kg / hr) for sedation written order, weeks old, wide open. intensive care and should enter propofol by continuous infusion.; infusion bewitching should be determined bewitching on the desired degree of sedation, for most patients, adequate sedation can be obtained by the introduction of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed the dose of 4 mg / kg / h; permanently the bewitching should not exceed 7 days for sedation in intensive therapy is not recommended to bewitching propofol infusion systems on the target concentration; adequate sedation bewitching surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are bewitching Surgical History doses of bewitching Propofol is rekomendovannyy bewitching use in children under bewitching year to ensure the induction of anesthesia in children, the drug should be slowly enter Liver Function Test any clinical signs of anesthesia. Side effects and complications in the use of drugs: anaphylactic shock, anaphylactic reaction, hypersensitivity reaction; hiperlipemiya, metabolic acidosis, hyperkalemia, euphoria, sexual illusion, involuntary movements, restlessness, headache, seizures, dizziness, decreased consciousness, hypotension, arrhythmia, bradycardia, nodalna tachycardia (in children), reduced cardiac output, hypertension (in children), hot flushes, asystole, heart failure, pulmonary edema, sleep apnea (transient), respiratory acidosis, cough, hyperventilation, nausea, vomiting, hiccups, pancreatitis, rash, itching (in children), muscle cramps, rhabdomyolysis, hromaturiya, pain, burning at the injection site, thrombosis, phlebitis at Intramuscular injection site, fever, fever, feeling cold. Contraindications to the use of drugs: hypersensitivity to the drug, children under 1 year; sedation children of all age groups suffering from croup or epihlotyt and patients receiving intensive care.
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